Applied Liposome Research Laboratory

liposome research, mitochondrial targeting, caveolae/raft, targeted drug delivery, contract research, ADME, CARPA, linkedin, liposome manufacturing, liposomal manufacturing, order liposomes, encapsulation technology

Some notes on the most serious adverse effect of the Doxil therapy

The FDA Doxil Label  contains a box warning that acute infusion-related reactions, occurred in up to 10% of patients. The reactions are serious and sometimes fatal allergic/anaphylactoid-like complications. Medications/emergency equipment to treat such reactions should be available for immediate use.

These infusion reactions are induced by complement activation (Complement Activation Related Pseudo Allergy - CARPA). Recently we developed a simple complement test that may predict the possible "allergic" reaction from the serum of the patient. Basically the test is the modification of the clinical complement fixation test. If you plan Doxil treatment for your patient please contact us and we tranfer the assay protocol free of charge.

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